CDw17 antigen

CDw17 antigen is a lactosylceramide,[1] a class of glycosphingolipids found in microdomains on the plasma layers of numerous cells. It is found on human neutrophils, basophils, monocyte, platelets, tonsillar CD45+ dendritic cells, epithelial cells, endothelial cells in intestinal epithelium, and on post-proliferative granulocytes in the bone marrow. [2]

CDw17 acts as a precursor for biosynthesis of glycosphingolipids.[3]

The enzyme A4GALT acts upon it, aiding transfer of galactose to lactosylceramide to form globotriaosylceramide.

References
  1. CDw17+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  2. Barclay AN, Brown MH, Law SK, McKnight AJ, Tomlinson MG, van der Merwe PA (1997). "CDw17". In Barclay AN (ed.). The Leucocyte Antigen Factsbook. Factsbook Series (2nd ed.). San Diego: Academic Press. p. 176. doi:10.1016/B978-012078185-0/50452-2. ISBN 978-0-12-078185-0.
  3. Chatterjee S, Balram A, Li W (February 2021). "Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes". International Journal of Molecular Sciences. 22 (4): 1816. doi:10.3390/ijms22041816. PMC 7917694. PMID 33673027.
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