Dobesilic acid

Dobesilic acid is a chemical compound with the molecular formula C6H6O5S. It is classified as both a phenol and a sulfonic acid.

Dobesilic acid
Names
IUPAC name
2,5-Dihydroxybenzenesulfonic acid
Other names
Hydroquinonesulfonic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard 100.001.667
EC Number
  • 201-833-4
UNII
  • InChI=1S/C6H6O5S/c7-4-1-2-5(8)6(3-4)12(9,10)11/h1-3,7-8H,(H,9,10,11)
    Key: IKQCSJBQLWJEPU-UHFFFAOYSA-N
  • C1=CC(=C(C=C1O)S(=O)(=O)O)O
Properties
C6H6O5S
Molar mass 190.17 g·mol−1
Related compounds
Other cations
 Calcium dobesilate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Uses

Salts of dobesilic are used as pharmaceutical drugs. The calcium salt, calcium dobesilate, is used as a vasoprotective drug.[1][2] The diethylamine salt, etamsylate, is an antihemorrhagic agent.[3]

References
  1. Zhang X, Liu W, Wu S, Jin J, Li W, Wang N (January 2015). "Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis". Science China Life Sciences. 58 (1): 101–7. doi:10.1007/s11427-014-4792-1. PMID 25528255.
  2. Haller H, Ji L, Stahl K, Bertram A, Menne J (2017). "Molecular Mechanisms and Treatment Strategies in Diabetic Nephropathy: New Avenues for Calcium Dobesilate-Free Radical Scavenger and Growth Factor Inhibition". BioMed Research International. 2017: 1909258. doi:10.1155/2017/1909258. PMC 5634607. PMID 29082239.
  3. Schulte J, Osborne J, Benson JW, Cooke R, Drayton M, Murphy J, et al. (January 2005). "Developmental outcome of the use of etamsylate for prevention of periventricular haemorrhage in a randomised controlled trial". Archives of Disease in Childhood. Fetal and Neonatal Edition. 90 (1): F31–F35. doi:10.1136/adc.2003.035790. PMC 1721806. PMID 15613570.
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