PIM3

PIM3
Identifiers
Aliases	PIM3, pim-3, Pim-3 proto-oncogene, serine/threonine kinase
External IDs	OMIM: 610580; MGI: 1355297; HomoloGene: 56955; GeneCards: PIM3; OMA:PIM3 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	49,964,072 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	88,749,929 bp[2]
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; skin of abdomen; ; skin of leg; ; body of stomach; ; upper lobe of left lung; ; minor salivary glands; ; left uterine tube; ; subcutaneous adipose tissue; ; right lung; ; gastrocnemius muscle;
	Top expressed in
	Paneth cell; ; lacrimal gland; ; vestibular membrane of cochlear duct; ; cumulus cell; ; parotid gland; ; motor neuron; ; facial motor nucleus; ; substantia nigra; ; endothelial cell of lymphatic vessel; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein serine/threonine kinase activity; protein kinase activity; protein binding; ATP binding;
Cellular component	cytoplasm; cytosol;
Biological process	protein autophosphorylation; protein phosphorylation; cell cycle; negative regulation of insulin secretion involved in cellular response to glucose stimulus; negative regulation of apoptotic process; phosphorylation; regulation of mitotic cell cycle; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	415116
	223775
	ENSG00000198355
	ENSMUSG00000035828
	Q86V86
	P58750
	NM_001001852
	NM_145478
	NP_001001852
	NP_663453
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase pim-3 is an enzyme that in humans is encoded by the PIM3 gene.[5]

References

GRCh38: Ensembl release 89: ENSG00000198355 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035828 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Atalay P, Ozpolat B (January 2024). "PIM3 Kinase: A Promising Novel Target in Solid Cancers". Cancers. 16 (3): 535. doi:10.3390/cancers16030535. PMC 10854964. PMID 38339286.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198355 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035828 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid38339286-5] Atalay P, Ozpolat B (January 2024). "PIM3 Kinase: A Promising Novel Target in Solid Cancers". Cancers. 16 (3): 535. doi:10.3390/cancers16030535. PMC 10854964. PMID 38339286.