STK33

STK33
Identifiers
Aliases	STK33, serine/threonine kinase 33
External IDs	OMIM: 607670; MGI: 2152419; HomoloGene: 75307; GeneCards: STK33; OMA:STK33 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	8,594,289 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	109,038,288 bp[2]
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; bronchial epithelial cell; ; left testis; ; right testis; ; olfactory zone of nasal mucosa; ; sperm; ; gonad; ; ventricular zone; ; testicle;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; epithelium of bronchiole; ; spermatogonium; ; medial ganglionic eminence; ; embryo; ; embryo; ; Jacobson's organ; ; outer plexiform layer;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; ATP binding; kinase activity; protein serine/threonine kinase activity;
Cellular component	cytoplasm; perinuclear region of cytoplasm; intracellular anatomical structure; nucleus;
Biological process	protein autophosphorylation; protein phosphorylation; phosphorylation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction; signal transduction in response to DNA damage; mitotic DNA damage checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	65975
	117229
	ENSG00000130413
	ENSMUSG00000031027
	Q9BYT3
	Q924X7
NM_001289058; NM_001289059; NM_001289061; NM_030906; NM_001352387;
	NM_001352388; NM_001352389; NM_001352390; NM_001352391; NM_001352392; NM_001352393; NM_001352394; NM_001352395; NM_001352396; NM_001352397; NM_001352398; NM_001352399
	NM_054103; NM_001355145
NP_001275987; NP_001275988; NP_001275990; NP_112168; NP_001339316;
	NP_001339317; NP_001339318; NP_001339319; NP_001339320; NP_001339321; NP_001339322; NP_001339323; NP_001339324; NP_001339325; NP_001339326; NP_001339327; NP_001339328
	NP_473444; NP_001342074
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine kinase 33 is a protein that in humans is encoded by the STK33 gene.

STK33 was identified as a synthetic lethal gene in KRAS-dependent cell lines.[5]

STK33 has been considered as a target for reversible male contraceptives and the inhibitor CDD-2807 has been tested successfully in mice.[6]

References

GRCh38: Ensembl release 89: ENSG00000130413 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000031027 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, et al. "Screen for Inhibitors of STK33 Kinase Activity". Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US). PMID 23658944.
https://www.nih.gov/news-events/nih-research-matters/drug-causes-reversible-male-contraception-mice

External links

STK33+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130413 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031027 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid23658944-5] Spoonamore J, Weïwer M, Wei J, Guichard B, Ross NT, Masson K, et al. "Screen for Inhibitors of STK33 Kinase Activity". Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US). PMID 23658944.

[6] ttps://www.nih.gov/news-events/nih-research-matters/drug-causes-reversible-male-contraception-mice

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)