No, the past perfect tense isn't required when using words like so, therefore, thus, etc. What you call "conclusory words" don't imply that the events in the clause they introduce happened before those in another clause. In fact, it can be the opposite. For example:
- She drove my car here, so I obviously had given her my keys.
- Jake admitted the truth only today and thus had lied about it yesterday.
The events that follow so and thus above actually precede those in their sentence's first clause and main clause, respectively, thus flipping the order. When telling a story, however, we often explain past events in the order they happened, so the past tense moves forward with the narrative. As such, we generally don't need to use the past perfect to indicate that the events we say first happened before events we say next because it's implied by the order we're saying it. For example:
- John unlocked the door, so I went inside.
- Grandma didn't give me a cookie, so I punched her in the nose.
- Everyone was being annoying, so we left.
Even though what happened in each first clause above happened before what happened in each second clause, we don't need the present perfect to say that. The progressing flow of the narrative is sufficient.
The only foreseeable rule regarding the past perfect in such sentences wouldn't be tenses that require the use of the past perfect but vice versa: If we use the past perfect, then we must use a past tense that isn't past-perfect somewhere else for an event more recent to justify the use of the past perfect. For example:
- Bob had called me nine times, so I called him back.
- He had lied to me. He had beaten me. He had cheated on me. He had even killed my dog. Therefore, I got a restraining order against him and then burned all his clothes on the front lawn.