Adverbs that end in -ly should not be hyphenated with verbs, so this is incorrect:
A carefully-written document.
But it's very common to hyphenate adverbs like 'well' with verbs, so this appears correct:
A well-prepared student.
Now I have seen compounds that include 'most' hyphenated and I'm not sure whether it is appropriate:
Saffron is the most-substituted ingredients in this recipe.
This is one of the most-read books of 2021.
Question: is there a rule (or rule of thumb) to determine whether a hyphen is required in adverb-verb compounds?