3-Methyl-GABA

3-Methyl-GABA
Names
	IUPAC name 4-Amino-3-methylbutanoic acid
	Other names HMS3266K11; HMS3411G19;
Identifiers
CAS Number	71135-23-4;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:93881;
ChEMBL	ChEMBL275655;
ChemSpider	2778160;
PubChem CID	3539719;
	InChI InChI=1S/C5H11NO2/c1-4(3-6)2-5(7)8/h4H,2-3,6H2,1H3,(H,7,8) Key: CZGLBWZXGIAIBU-UHFFFAOYSA-N;
	SMILES CC(CC(=O)O)CN;
Properties
Chemical formula	C5H11NO2
Molar mass	117.148 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

3-Methyl-GABA, also known as HMS3266K11, is an anticonvulsant alkaloid.

Pharmacology

3-Methyl-GABA is an activator of GABA-T, an enzyme that transforms GABA to succinate semialdehyde and glutamate.[1]

It also activates glutamate decarboxylase, an enzyme that is needed in GABA synthesis. This is thought to be the primary mechanism of action behind its anticonvulsant action.[2][3]

References

https://www.tocris.com/products/3-methyl-gaba_0386
https://www.medchemexpress.com/3-methyl-gaba.html
Silverman, Richard B.; Andruszkiewicz, Ryszard; Nanavati, Shrenik M.; Taylor, Charles P.; Vartanian, Mark G. (1991). "3-Alkyl-4-aminobutyric acids: The first class of anticonvulsant agents that activates L-glutamic acid decarboxylase". Journal of Medicinal Chemistry. 34 (7): 2295–2298. doi:10.1021/jm00111a053. PMID 2067001.

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[1] ttps://www.tocris.com/products/3-methyl-gaba_0386

[2] ttps://www.medchemexpress.com/3-methyl-gaba.html

[3] Silverman, Richard B.; Andruszkiewicz, Ryszard; Nanavati, Shrenik M.; Taylor, Charles P.; Vartanian, Mark G. (1991). "3-Alkyl-4-aminobutyric acids: The first class of anticonvulsant agents that activates L-glutamic acid decarboxylase". Journal of Medicinal Chemistry. 34 (7): 2295–2298. doi:10.1021/jm00111a053. PMID 2067001.