FOSL1

FOSL1
Identifiers
Aliases	FOSL1, FRA, FRA1, fra-1, FOS like 1, AP-1 transcription factor subunit
External IDs	OMIM: 136515; MGI: 107179; HomoloGene: 3967; GeneCards: FOSL1; OMA:FOSL1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	65,900,573 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	5,505,974 bp[2]
RNA expression pattern
	Top expressed in
	cartilage tissue; ; stromal cell of endometrium; ; gallbladder; ; vena cava; ; mucosa of urinary bladder; ; mucosa of esophagus; ; testicle; ; islet of Langerhans; ; ascending aorta; ; cervix epithelium;
	Top expressed in
	endothelial cell of lymphatic vessel; ; granulocyte; ; decidua; ; embryo; ; embryo; ; gastrula; ; stroma of bone marrow; ; supraoptic nucleus; ; lip; ; ascending aorta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytosol; intracellular membrane-bounded organelle; neuron projection; presynaptic membrane; nucleus; nucleoplasm;
Biological process	cellular response to extracellular stimulus; response to cytokine; regulation of transcription, DNA-templated; response to organic cyclic compound; vitellogenesis; regulation of transcription by RNA polymerase II; response to progesterone; female pregnancy; response to corticosterone; response to mechanical stimulus; response to virus; positive regulation of DNA-binding transcription factor activity; placenta blood vessel development; in utero embryonic development; learning; positive regulation of DNA-templated transcription, initiation; chemotaxis; response to gravity; cellular defense response; positive regulation of cell cycle; positive regulation of cell population proliferation; positive regulation of apoptotic process; response to cAMP; response to hydrogen peroxide; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; pri-miRNA transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8061
	14283
	ENSG00000175592
	ENSMUSG00000024912
	P15407
	P48755
	NM_001300844; NM_001300855; NM_001300856; NM_001300857; NM_005438
	NM_010235
	NP_001287773; NP_001287784; NP_001287785; NP_001287786; NP_005429
	NP_034365
	Wikidata
View/Edit Human	View/Edit Mouse

Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.[5][6]

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[6]

Interactions

FOSL1 has been shown to interact with USF1 (human gene)[7] and C-jun.[7]

References

GRCh38: Ensembl release 89: ENSG00000175592 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024912 – Ensembl, May 2017
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External links

FOSL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
FactorBook FOSL1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175592 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024912 – Ensembl, May 2017

[3] Lua error in Module:Citation/CS1/Configuration at line 2058: attempt to index a boolean value.

[4] Lua error in Module:Citation/CS1/Configuration at line 2058: attempt to index a boolean value.

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FOSL1

Function

Interactions

See also

References

Further reading

External links