Sarolaner

Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs.[5][6] It is also used off-label to control sarcoptic mange and demodectic mange.[6]

Sarolaner
Clinical data
Trade namesSimparica
Other namesPF-6450567
ATCvet code
Legal status
Legal status
Identifiers
  • 1-[6-[(5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.234.000
Chemical and physical data
FormulaC23H18Cl2F4N2O5S
Molar mass581.36 g·mol−1
3D model (JSmol)
  • CS(=O)(=O)CC(=O)N1CC2(C1)OCc1cc(C3=NO[C@@](c4cc(Cl)c(F)c(Cl)c4)(C(F)(F)F)C3)ccc12
  • InChI=1S/C23H18Cl2F4N2O5S/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6H,7-11H2,1H3/t22-/m0/s1
  • Key:FLEFKKUZMDEUIP-QFIPXVFZSA-N

Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel.[7][8] It is used for prevention of heartworm disease caused by Dirofilaria immitis; treat and prevent flea infestations; treat and control tick infestations with the lone star tick, Gulf Coast tick, American dog tick, black-legged tick, and brown dog tick; and treat and control roundworm and adult hookworm infections.[9]

Sarolaner is also an ingredient in feline combination antiparasitic Revolution Plus (or Stronghold Plus[10]), which contains sarolaner and selamectin and is used for prevention of sarcoptic mange, feline hookworms, feline roundworms, ear mites, and heartworms, as well as treating and preventing fleas and ticks.[11]

References
  1. "Approved in 2020: Drugs for human use". Health Canada. 26 July 2021. Retrieved 27 March 2024.
  2. "Simparica". U.S. Food and Drug Administration (FDA). Retrieved 12 December 2022.
  3. "Simparica EPAR". European Medicines Agency. 18 December 2015. Retrieved 13 June 2024.
  4. "MiPet Easecto EPAR". European Medicines Agency. 23 February 2018. Retrieved 13 June 2024.
  5. McTier TL, Chubb N, Curtis MP, Hedges L, Inskeep GA, Knauer CS, et al. (May 2016). "Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs" (PDF). Veterinary Parasitology. 222: 3–11. doi:10.1016/j.vetpar.2016.02.019. PMID 26961590.
  6. Gollakner R. "Sarolaner". vcahospitals.com. VCA Hospitals. Retrieved 26 June 2021.
  7. "Simparica Trio". U.S. Food and Drug Administration (FDA). Retrieved 12 December 2022.
  8. "Simparica Trio EPAR". European Medicines Agency. 14 October 2019. Retrieved 15 June 2024.
  9. "FDA Approves Simparica Trio, a Combination Drug for Heartworm and Other Parasites". U.S. Food and Drug Administration (FDA). 2 March 2020. Retrieved 26 June 2021.
  10. "Stronghold Plus". European Medicines Agency. Retrieved 12 December 2022.
  11. "Revolution Plus". U.S. Food and Drug Administration (FDA). Retrieved 12 December 2022.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.